Hydrogels for eye diseases
We developed an alternative to eye drops and ointment to treat eye diseases. The active ingredients they contain are often poorly absorbed or quickly degraded. Innovative electrospin fleeced, which dissolve quickly after placing on the eye and form a hydrogel, will be used. Thus, the active ingredients can have a longer effect on theeye and are absorbed into the tear fluid leading to more efficient therapy. In addition, these hycompletelydrogels have a better shelf life and tolerability.
Publications
Heinzelmann, J.; Stoica, S.; Vogt, A. R.; Hecht, S.; Viestenz, A.; Viestenz, A. Intraocular Epithelial Ingrowth after Traumatic and Surgical Corneal Injuries. Diagnostics (Basel) 2024, 14 (13). DOI: 10.3390/diagnostics14131401
Lehner, E.; Liebau, A.; Menzel, M.; Schmelzer, C. E. H.; Knolle, W.; Scheffler, J.; Binder, W. H.; Plontke, S. K.; Mäder, K. Characterization of PLGA versus PEG-PLGA intracochlear drug delivery implants: Degradation kinetics, morphological changes, and pH alterations. Journal of Drug Delivery Science and Technology 2024, 99. DOI: https://doi.org/10.1016/j.jddst.2024.105972
Meinhard, S.; Erdmann, F.; Lucas, H.; Krabbes, M.; Krüger, S.; Wölk, C.; Mäder, K. T14diLys/DOPE Liposomes: An Innovative Option for siRNA-Based Gene Knockdown? Pharmaceutics 2024, 17 (1). DOI: https://doi.org/10.3390/pharmaceutics17010025.
Göttel B, de Souza E Silva JM, Santos de Oliveira C, Syrowatka F, Fiorentzis M, Viestenz A, Viestenz A, Mäder K. Electrospun nanofibers – A promising solid in-situ gelling alternative for ocular drug delivery. Eur J Pharm Biopharm. 2020;146:125-132. doi: 10.1016/j.ejpb.2019.11.012
Göttel B, Lucas H, Syrowatka F, Knolle W, Kuntsche J, Heinzelmann J, Viestenz A, Mäder K. In situ Gelling Amphotericin B Nanofibers: A New Option for the Treatment of Keratomycosis. Front Bioeng Biotechnol. 2020, 21;8:600384. doi: 10.3389/fbioe.2020.600384.
Patents / Awards
Hugo Junkers Prize 2023
1st prize „Innovativste Vorhaben der Grundlagenforschung
https://www.hugo-junkers-preis.de/preistraeger/preistraeger-2023