3D-printed tissue & proteins
3D bioprinting allows for the precise fabrication of complex biological tissues and organs, which could be used to repair or replace damaged tissues in the body. It can also be used to create personalized medical implants and devices that are tailored to the individual patient. We use 3D tissue cultures, scaffolds based on extracellular matrix components and study their combination with sensors. The field of 3D bioprintingis still in its early stages, but it has the potential to revolutionize the way we treat diseases and injuries.
Publications
Lehner, E.; Liebau, A.; Menzel, M.; Schmelzer, C. E. H.; Knolle, W.; Scheffler, J.; Binder, W. H.; Plontke, S. K.; Mäder, K. Characterization of PLGA versus PEG-PLGA intracochlear drug delivery implants: Degradation kinetics, morphological changes, and pH alterations. Journal of Drug Delivery Science and Technology 2024, 99. DOI: https://doi.org/10.1016/j.jddst.2024.105972
Collins, R. T., 2nd; Gravenhorst, V.; Faury, G.; Kwiatkowska, J.; Schmelzer, C. E. H.; Schneider, H.; Waldoch, A.; Pankau, R. Clinical Care for Cardiovascular Disease in Patients With Williams-Beuren Syndrome. J Am Heart Assoc 2024, 13 (19), e036997. DOI: 10.1161/JAHA.124.036997
Prasoon, A.; Ghouse, S.; Nguyen, N. N.; Yang, H.; Muller, A.; Naisa, C.; Paasch, S.; Herbawe, A.; Aiti, M. A.; Cuniberti, G.; Brunner, E.; Feng, X. Mimicking on-water surface synthesis through micellar interfaces. Nat Commun 2024, 15 (1), 10495. DOI: 10.1038/s41467-024-54962-z
Baudis, S.; Roch, T.; Balk, M.; Wischke, C.; Lendlein, A.; Behl, M. Multivariate Analysis of Cellular Uptake Characteristics for a (Co)polymer Particle Library. ACS Biomater Sci Eng 2024, 10 (3), 1481-1493. DOI: 10.1021/acsbiomaterials.3c01803
Hautmann, A.; Hedtke, T.; Sislema-Muñoz, S.; Martins-Schalinski, J.; Schmelzer, C. E. H.; Groth, T. Design of a composite wound dressing: Combining an electrospun fleece with a free-standing multilayer film. Next Materials 2024, 2. DOI: https://doi.org/10.1016/j.nxmate.2023.100060.
J. Li, A. Reimers, K.M. Dang, M.G.K. Brunk, J. Drewes, U.M. Hirsch, C. Willems, C.E.H. Schmelzer, T. Groth, A.S. Nia, X. Feng, F. Schütt, W.D. Sacher, R. Adelung, J.K.S. Poon, 3D printed neural tissues with in situ optical dopaminesensors, Biosens. Bioelectron. 222, 114942 (2023) DOI: 10.1016/j.bios.2022.114942
Collaborative research centers / Network
Patents / Awards
Patent „A process for 3D bioprinting utilizing a hydrogel comprising a water-soluble elastin derivative” (EP 22 195 467.0), Friedmann, A.; Hedtke, T.; Schmelzer, C.