Carbohydrates
Biological molecules such as carbohydrates, proteins and lipids decorate the surface of all cells, regulating a multitude of biological mechanisms like cell-cell-recognition and cell-communication. We use in silico-design strategies and automated synthetic assembly to prepare well-defined receptors and recognition patterns. These synthetic structures can be printed on surfaces, conjugated to other (nano)materials, assembled into supramolecular structures to mimic biological interfaces and integrated into (sequence-defined) functional polymers to decorate interfaces and to control interactions with cellular assemblies & tissue.
Prof. Dr. Daniel Wefers
Publications
Münkel, F., Bechtner, J., Eckel, V., Fischer, A., Herbi, F., Jakob, F., Wefers, D. Detailed structural characterization of glucans produced by glucansucrases from Leuconostoc citreum TMW 2.1194. J. Agric. Food Chem. 2019, 67, 6856-6866.
Münkel, F., Fischer, A., Wefers, D. Structural characterization of mixed-linkage α-glucans produced by mutants of Lactobacillus reuteri TMW 1.106 dextransucrase. Carbohydr. Polym. 2020, 231, 115697.
Klingel, T., Hadamjetz, M., Fischer, A., Wefers, D. Glucosylation of flavonoids and flavonoid glycosides by mutant dextransucrase from Lactobacillus reuteri TMW 1.106. Carbohydr. Res. 2019, 483, 107741.
Klingel, T., Bindereif, B., Hadamjetz, M., Fischer, A., van der Schaaf, U.S., Wefers, D. Enzymatic synthesis and characterization of mono-, oligo-, and polyglucosylated conjugates of caffeic acid and gallic acid. J. Agric. Food Chem. 2019, 67, 13108-13118.
Dr. Matthias Hartlieb
Dr. Martina Delbianco
Prof. Dr. Helmut Schlaad
Publications
Fittolani, G., Vargová, D., Seeberger, P. H., Ogawa, Y. & Delbianco, M. Bottom-Up Approach to Understand ChiralityTransfer across Scales in Cellulose Assemblies. J. Am. Chem. Soc. 2022, 144, 12469-12475. https://doi.org:10.1021/jacs.2c04522
Lehnen, A.-C., Bapolisi, A. M., Reifarth, M., Bekir, M., Hartlieb, M. Xanthate-supported photo-iniferter (XPI)-RAFT polymerization: Facile and rapid access to complex macromolecular architectures. Chem. Sci., 2023, 14, 593-603. https://doi.org/10.1039/D2SC05197D
Lüdecke, N., Bekir, M., Eickelmann, S., Hartlieb, M., Schlaad, H. Toward Protein-Repellent Surface Coatings fromCatechol-containing Cationic Poly(2-ethyl-2-oxazoline) ACS Appl. Mater. Interfaces, 2023, 15, 19582-19592, https://doi.org/10.1021/acsami.2c22518
Collaborative research centers / Network
Patents / Awards
ERC starting grant, GLYCOFOLD – 101075357 (1,499,956 €) | Martina Delbianco
DFG Emmy Noether grant, Potsdam (1,645,000 €) | Matthias Hartlieb
BMBF NanoMatFutur – CarboMat 13XP5114 (1,595,600 €) | Martina Delbianco