EPR and NMR of (Bio)Polymers
Magnetic resonance (MR) spectroscopy uses the electron spin (EPR) or nuclear spin (NMR) to characterize the structure, dynamics and thus the function of biomacromolecules at molecular resolution. The main focus are the physico-chemical and biophysical properties of proteins and how these relate to the generic properties of these biomacromolecules and their biological function. They include membrane and medically relevant proteins and their interaction with the biological environment and functional substrates.
Prof. Dr. Dariush Hinderberger
Prof. Dr. Jochen Balbach
Publications
Hoffmann, M; Haselberger, D.; Hofmann, T.; Müller, L.; Janson, K.; Meister, A.; Das, M.; Vargas, C.; Keller, S.; Kastritis, P.: Schmidt, C.; Hinderberger, D. A Nanoscale Model System for the Human Myelin Sheath. Biomacromolecules 2021, 22, 3901–3912. https://doi.org/10.1021/acs.biomac.1c00714
Gruber, T.; Lewitzky, M.; Machner, L.; Weininger, U.; Feller, S. M.; Balbach, J. Macromolecular crowding induces a binding competent transient structure in intrinsically disordered Gab1. J. Mol. Biol. 2022, 434, 167407-167422, https://doi.org/10.1016/j.jmb.2021.167407
Evgrafova, Z., Voigt B., Roos A. H., Hause, G.; Hinderberger, D.; Balbach, J.; Binder, W. H. Modulation of amyloid β peptide aggregation by hydrophilic polymers. PhysChemChemPhys 2019, 21 (37):20999-21006.https://doi.org/10.1039/c9cp02683e
Collaborative research centers / Network
Patents / Awards
Profound Changes in Functional Structure and Dynamics of Serum Albumin in Children with Nephrotic Syndrome: An Exploratory Research Study
Haeri, Haleh H.; Eisermann, J.; Schimm, H.; Büscher, A.; Hoyer, P.; Hinderberger, D. J. Med. Chem. 2023, in press (accepted 07 Aug 2023).
Translation of basic biopolymer research into medical applications
Balbach, J.; Stubbs, M. T. Science 2023, 381(6654), 126-127, https://doi: 10.1126/science.adi7571