Hydrogels for eye diseases
We developed an alternative to eye drops and ointment to treat eye diseases. The active ingredients they contain are often poorly absorbed or quickly degraded. Innovative electrospin fleeced, which dissolve quickly after placing on the eye and form a hydrogel, will be used. Thus, the active ingredients can have a longer effect on theeye and are absorbed into the tear fluid leading to more efficient therapy. In addition, these hycompletelydrogels have a better shelf life and tolerability.
Prof. Dr. Karsten Mäder
Prof. Dr. Arne Viestenz
Dr. Joana Heinzelmann
Publications
Göttel B, de Souza E Silva JM, Santos de Oliveira C, Syrowatka F, Fiorentzis M, Viestenz A, Viestenz A, Mäder K. Electrospun nanofibers – A promising solid in-situ gelling alternative for ocular drug delivery. Eur J Pharm Biopharm. 2020;146:125-132. doi: 10.1016/j.ejpb.2019.11.012
Göttel B, Lucas H, Syrowatka F, Knolle W, Kuntsche J, Heinzelmann J, Viestenz A, Mäder K. In situ Gelling Amphotericin B Nanofibers: A New Option for the Treatment of Keratomycosis. Front Bioeng Biotechnol. 2020, 21;8:600384. doi: 10.3389/fbioe.2020.600384.
Patents / Awards
Hugo Junkers Prize 2023
1st prize „Innovativste Vorhaben der Grundlagenforschung
https://www.hugo-junkers-preis.de/preistraeger/preistraeger-2023