Fibrosis & Immunology
Any non-self surface activates the first response of the immune system, the innate immune cascade complement. This leads to cell activation that can culminate in a fibrosis response to enclose biomaterials resulting in the failure of the intended applications. We will engage at different levels of these processes to define the underlying bio-responses at a molecular level. Consequently, we will generate tailor-made applications to overcome these detrimental, unwanted body responses to stir the function and lifetime of modern biomaterials.
Prof. Dr. Sonja M. Keßler
Publications
Kendzia, S.; et int; Kessler, S. M. A combined computational and functional approach identifies IGF2BP2 as a driver of chemoresistance in a wide array of pre-clinical models of colorectal cancer. Mol Cancer 2023 22:89, https://doi.org/10.1186/s12943-023-01787-x
Czepukojc, B.; Barghash, A.; Tierling, S.; Simon, Y.; Körbel, C.; Cadenas, C.; van Hul, N.; Sachinidis, A.; Hengstler, J.G.; Helms, V.; Laschke, M.W.; Walter, J.; Haybaeck, J.; Leclercq, I.; Kiemer, A.K.; Kessler, S.M. IGF2 mRNABinding Protein 2 Transgenic Mice Are More Prone to Develop a Ductular Reaction and to Progress Toward Cirrhosis. Front Med 2019 6, 179, https://doi.org/10.3389/fmed.2019.00179
Collaborative research centers / Network
