Protein and Cell Engineering
Enzymes catalyze various natural reactions in biology. Protein engineering has arisen to optimize enzymes for diverse applications by modifying them iteratively, both randomly and rationally. This process involves designing specific enzyme properties deliberately. Incorporating machine learning, rapid protein structure access, and improved feedback from random screening has significantly hastened advances in protein engineering.random screening endeavors have collectively accelerated progress within the realm of protein engineering.
(smart.servier.com)
Prof. Dr. Martin Weissenborn
Publications
Münch J, Soler J, Hünecke N, Homann D, Garcia-Borràs M, Weissenborn MJ. Computational-Aided Engineering of a Selective Unspecific Peroxygenase toward Enantiodivergent-ß-Ionone Hydroxylation. ACS Catalysis 2023, 13, 8963-8972, https://doi.org/10.1021/acscatal.3c01997
Püllmann P, Homann D, Karl TA, König B, Weissenborn MJ. Light-Controlled Biocatalysis by Unspecific Peroxygenases with Genetically Encoded Photosensitizers. Angew. Chem. Int. Ed. 2023, 62, e202307897, https://doi.org/10.1002/anie.202307897
Collaborative research centers / Network
